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TitleDiscovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 2299-2304, Year 2007
Publish dateJan 2, 2007 (structure data deposition date)
AuthorsMartin, M.W. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / McGowan, D.C. / White, R.D. / Buchanan, J.L. / Dimauro, E.F. / Boucher, C. / Faust, T. ...Martin, M.W. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / McGowan, D.C. / White, R.D. / Buchanan, J.L. / Dimauro, E.F. / Boucher, C. / Faust, T. / Hsieh, F. / Huang, X. / Lee, J.H. / Schneider, S. / Turci, S.M. / Zhu, X.
External linksBioorg. Med. Chem. Lett. / PubMed:17276681
MethodsX-ray diffraction
Resolution2 - 2.7 Å
Structure data

PDB-2of2:
crystal structure of furanopyrimidine 8 bound to lck
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2of4:
crystal structure of furanopyrimidine 1 bound to lck
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-547:
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE

ChemComp-HOH:
WATER

ChemComp-979:
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / lck / kinase domain

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