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TitleIdentification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 1679-1683, Year 2007
Publish dateDec 19, 2006 (structure data deposition date)
AuthorsCheney, I.W. / Yan, S. / Appleby, T. / Walker, H. / Vo, T. / Yao, N. / Hamatake, R. / Hong, Z. / Wu, J.Z.
External linksBioorg. Med. Chem. Lett. / PubMed:17251021
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-2obj:
Crystal structure of human PIM-1 Kinase in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-VRV:
6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PIM / PIM-1 / PIM1 / human PIM-1 Kinase / Serine/threonine kinase / kinase inhibitor complex / Pyridone / kinase inhibitor

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