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TitleHighly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Journal, issue, pagesJ. Med. Chem., Vol. 50, Page 3777-3785, Year 2007
Publish dateDec 18, 2006 (structure data deposition date)
AuthorsMarino, J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R.B. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, M.D. ...Marino, J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R.B. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, M.D. / Schulz, C. / Smith, W.W. / Tew, D.G. / Tomazek, T.A. / Veber, D.F. / Xiong, W.C. / Yamamoto, Y. / Yamashita, K. / Yang, G. / Thompson, S.K.
External linksJ. Med. Chem. / PubMed:17636946
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2oaz:
Human Methionine Aminopeptidase-2 Complexed with SB-587094
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-I96:
N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / MetAP2 / Methionine / Amino Peptidase

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