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Title | Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 2005-2012, Year 2007 |
Publish date | Dec 15, 2006 (structure data deposition date) |
Authors | Backes, B.J. / Longenecker, K. / Hamilton, G.L. / Stewart, K. / Lai, C. / Kopecka, H. / von Geldern, T.W. / Madar, D.J. / Pei, Z. / Lubben, T.H. ...Backes, B.J. / Longenecker, K. / Hamilton, G.L. / Stewart, K. / Lai, C. / Kopecka, H. / von Geldern, T.W. / Madar, D.J. / Pei, Z. / Lubben, T.H. / Zinker, B.A. / Tian, Z. / Ballaron, S.J. / Stashko, M.A. / Mika, A.K. / Beno, D.W. / Kempf-Grote, A.J. / Black-Schaefer, C. / Sham, H.L. / Trevillyan, J.M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:17276063 |
Methods | X-ray diffraction |
Resolution | 2.3 - 3 Å |
Structure data | PDB-2oae: PDB-2oag: |
Chemicals | ChemComp-SO4: ChemComp-AIL: ChemComp-DLI: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / serine-peptidase / inhibitor complex / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |