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TitleCrystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Journal, issue, pagesStructure, Vol. 14, Page 1835-1844, Year 2006
Publish dateNov 2, 2006 (structure data deposition date)
AuthorsWang, Z. / Liu, J. / Sudom, A. / Ayres, M. / Li, S. / Wesche, H. / Powers, J.P. / Walker, N.P.C.
External linksStructure / PubMed:17161373
MethodsX-ray diffraction
Resolution2 - 2.15 Å
Structure data

PDB-2nru:
Crystal structure of IRAK-4
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2nry:
Crystal structure of IRAK-4
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-T12:
1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE

ChemComp-HOH:
WATER

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / inhibitor / IRAK / staurosporine

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