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-Structure paper
Title | Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. |
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Journal, issue, pages | J. Biol. Chem., Vol. 283, Page 17227-17237, Year 2008 |
Publish date | Oct 24, 2006 (structure data deposition date) |
![]() | Schoch, G.A. / Yano, J.K. / Sansen, S. / Dansette, P.M. / Stout, C.D. / Johnson, E.F. |
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Methods | X-ray diffraction |
Resolution | 2.28 - 2.8 Å |
Structure data | ![]() PDB-2nnh: ![]() PDB-2nni: ![]() PDB-2nnj: ![]() PDB-2vn0: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HEM: ![]() ChemComp-9CR: ![]() ChemComp-PLM: ![]() ChemComp-HOH: ![]() ChemComp-MTK: ![]() ChemComp-225: ![]() ChemComp-TDZ: |
Source |
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![]() | OXIDOREDUCTASE / ELECTRON TRANSPORT / CYP2C8; Human P450 2C8; monooxygenases; substrate complex; palmitic acid; 9-cis retinoic acid; panretin / CYP2C8; Human P450 2C8; monooxygenases; Montelukast; Singulair; inhibitor complex; palmitic aci / CYP2C8; Human P450 2C8; monooxygenases; Felodipine; Plendil; inhibitor complex; palmitic acid / ENDOPLASMIC RETICULUM / METAL-BINDING / PALMITIC ACID / HUMAN P450 2C8 / TROGLITAZONE / POLYMORPHISM / MONOOXYGENASE / IRON / HEME / CYP2C8 / MEMBRANE / MICROSOME / MONOOXYGENASES / INHIBITOR COMPLEX |