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TitleTrio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 3525-3530, Year 2013
Publish dateSep 14, 2012 (structure data deposition date)
AuthorsVlach, J. / Saad, J.S.
External linksProc. Natl. Acad. Sci. USA / PubMed:23401539
MethodsNMR (solution)
Structure data

PDB-2lya:
Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidylcholine
Method: SOLUTION NMR

PDB-2lyb:
Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidyl-L-serine
Method: SOLUTION NMR

Chemicals

ChemComp-PC8:
1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

ChemComp-8SP:
O-[(R)-{[(2R)-2,3-bis(octanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine

Source
  • human immunodeficiency virus type 1
KeywordsVIRAL PROTEIN / Gag / matrix / plasma membrane / lipid

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