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TitleMacrocyclic Aminopyrimidines as Multitarget Cdk and Vegf-R Inhibitors with Potent Antiproliferative Activities.
Journal, issue, pagesChemmedchem, Vol. 2, Page 63-, Year 2007
Publish dateNov 13, 2006 (structure data deposition date)
AuthorsLuecking, U. / Siemeister, G. / Schaefer, M. / Briem, H. / Krueger, M. / Lienau, P. / Jautelat, R.
External linksChemmedchem / PubMed:17131463
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-2j9m:
Crystal Structure of CDK2 in complex with Macrocyclic Aminopyrimidine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PY8:
6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE-THREONINE PROTEIN KINASE / SERINE/THREONINE-PROTEIN KINASE / NUCLEOTIDE-BINDING / ARYLAMINE N-ACETYLTRANSFERASE / CELL DIVISION / DRUG METABOLISM / PHOSPHORYLATION / ATP-BINDING / MYCOBACTERIA / NAT / KINASE / MITOSIS / ISONIAZID / CELL CYCLE

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