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Title1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 7247-7251, Year 2006
Publish dateSep 8, 2006 (structure data deposition date)
AuthorsFancelli, D. / Moll, J. / Varasi, M. / Bravo, R. / Artico, R. / Berta, D. / Bindi, S. / Cameron, A. / Candiani, I. / Cappella, P. ...Fancelli, D. / Moll, J. / Varasi, M. / Bravo, R. / Artico, R. / Berta, D. / Bindi, S. / Cameron, A. / Candiani, I. / Cappella, P. / Carpinelli, P. / Croci, W. / Forte, B. / Giorgini, M.L. / Klapwijk, J. / Marsiglio, A. / Pesenti, E. / Rocchetti, M. / Roletto, F. / Severino, D. / Soncini, C. / Storici, P. / Tonani, R. / Zugnoni, P. / Vianello, P.
External linksJ. Med. Chem. / PubMed:17125279
MethodsX-ray diffraction
Resolution2 - 3 Å
Structure data

PDB-2j4z:
Structure of Aurora-2 in complex with PHA-680626
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2j50:
Structure of Aurora-2 in complex with PHA-739358
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-626:
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE

ChemComp-ARS:
ARSENIC

ChemComp-HOH:
WATER

ChemComp-627:
N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PHOSPHORYLATION / NUCLEOTIDE-BINDING / KINASE / CELL CYCLE / ATP-BINDING / NUCLEOTIDE- BINDING / SERINE/THREONINE-PROTEIN KINASE / SERINE-THREONINE-PROTEIN KINASE

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