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TitleRmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
Journal, issue, pagesJ. Mol. Biol., Vol. 365, Page 146-, Year 2007
Publish dateJul 7, 2006 (structure data deposition date)
AuthorsDong, C. / Major, L.L. / Srikannathasan, V. / Errey, J.C. / Giraud, M.F. / Lam, J.S. / Graninger, M. / Messner, P. / Mcneil, M.R. / Field, R.A. ...Dong, C. / Major, L.L. / Srikannathasan, V. / Errey, J.C. / Giraud, M.F. / Lam, J.S. / Graninger, M. / Messner, P. / Mcneil, M.R. / Field, R.A. / Whitfield, C. / Naismith, J.H.
External linksJ. Mol. Biol. / PubMed:17046787
MethodsX-ray diffraction
Resolution1.6 - 2.54 Å
Structure data

PDB-2ixc:
RmlC M. tuberculosis with dTDP-rhamnose
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-2ixh:
RmlC P aeruginosa with dTDP-rhamnose
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2ixi:
RmlC P aeruginosa with dTDP-xylose
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2ixj:
RmlC P aeruginosa native
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

PDB-2ixk:
RmlC P aeruginosa with dTDP-4-keto rhamnnose (the product of the reaction)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2ixl:
RmlC S. suis with dTDP-rhamnose
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-TRH:
2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE

ChemComp-HOH:
WATER

ChemComp-TYD:
THYMIDINE-5'-DIPHOSPHATE

ChemComp-SRT:
S,R MESO-TARTARIC ACID

ChemComp-TDO:
DTDP-4-KETO-L-RHAMNOSE

ChemComp-NI:
NICKEL (II) ION

Source
  • mycobacterium tuberculosis (bacteria)
  • pseudomonas aeruginosa (bacteria)
  • streptococcus suis (bacteria)
KeywordsISOMERASE / LIPOPOLYSACCHARIDE BIOSYNTHESIS / EPIMERISE / EPIMERASE / EPIMERIZE

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