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Structure paper

TitleStructure and Chemical Inhibition of the Ret Tyrosine Kinase Domain.
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 33577-33587, Year 2006
Publish dateJun 16, 2006 (structure data deposition date)
AuthorsKnowles, P.P. / Murray-Rust, J. / Kjaer, S. / Scott, R.P. / Hanrahan, S. / Santoro, M. / Ibanez, C.F. / McDonald, N.Q.
External linksJ. Biol. Chem. / PubMed:16928683
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-2ivs:
Crystal structure of non-phosphorylated RET tyrosine kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2ivt:
Crystal structure of phosphorylated RET tyrosine kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2ivu:
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor ZD6474
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2ivv:
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor PP1
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-ACK:
2',3'- cyclic AMP

ChemComp-HOH:
WATER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-ZD6:
Vandetanib / medication, anticancer, inhibitor*YM

ChemComp-PP1:
1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / NUCLEOTIDE-BINDING / HIRSCHSPRUNG DISEASE / PHOSPHORYLATION / DISEASE MUTATION / PHOSPHOTRANSFERASE / TYROSINE-PROTEIN KINASE / CHROMOSOMAL TRANSLOCATION / POLYMORPHISM / GDNF RECEPTOR / TRANSMEMBRANE / PROTO-ONCOGENE / TYROSINE KINASE / RET / KINASE / MEMBRANE / ATP-BINDING

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