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TitleDiscovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 750-755, Year 2007
Publish dateOct 16, 2006 (structure data deposition date)
AuthorsPatel, J.R. / Shuai, Q. / Dinges, J. / Winn, M. / Pliushchev, M. / Fung, S. / Monzon, K. / Chiou, W. / Wang, J. / Pan, L. ...Patel, J.R. / Shuai, Q. / Dinges, J. / Winn, M. / Pliushchev, M. / Fung, S. / Monzon, K. / Chiou, W. / Wang, J. / Pan, L. / Wagaw, S. / Engstrom, K. / Kerdesky, F.A. / Longenecker, K. / Judge, R. / Qin, W. / Imade, H.M. / Stolarik, D. / Beno, D.W. / Brune, M. / Chovan, L.E. / Sham, H.L. / Jacobson, P. / Link, J.T.
External linksBioorg. Med. Chem. Lett. / PubMed:17110106
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-2irw:
Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-NN4:
(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / HSD1 / NADP / inhibitor

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