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-Structure paper
Title | Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097. |
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Journal, issue, pages | J. Mol. Biol., Vol. 365, Page 77-89, Year 2007 |
Publish date | Sep 8, 2006 (structure data deposition date) |
Authors | Das, K. / Sarafianos, S.G. / Clark, A.D. / Boyer, P.L. / Hughes, S.H. / Arnold, E. |
External links | J. Mol. Biol. / PubMed:17056061 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3 Å |
Structure data | PDB-2iaj: PDB-2ic3: |
Chemicals | ChemComp-MN: ChemComp-NA: ChemComp-ATP: ChemComp-GOL: ChemComp-HOH: ChemComp-HBY: |
Source |
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Keywords | TRANSFERASE / RT / NNRTI / NONNUCLEOSIDE INHIBITOR / DRUG RESISTANCE / DNA POLYMERIZATION / HIV / AIDS / DRUG DESIGN |