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TitleMimicking damaged DNA with a small molecule inhibitor of human UNG2.
Journal, issue, pagesNucleic Acids Res., Vol. 34, Page 5872-5879, Year 2006
Publish dateAug 3, 2006 (structure data deposition date)
AuthorsKrosky, D.J. / Bianchet, M.A. / Seiple, L. / Chung, S. / Amzel, L.M. / Stivers, J.T.
External linksNucleic Acids Res. / PubMed:17062624
MethodsX-ray diffraction
Resolution1.3 Å
Structure data

PDB-2hxm:
Complex of UNG2 and a small Molecule synthetic Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-302:
4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / DNA REPAIR / URACIL / URACIL DNA GLYCOSYLASE

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