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Title | Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. |
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Journal, issue, pages | J. Mol. Biol., Vol. 363, Page 161-173, Year 2006 |
Publish date | Jul 20, 2006 (structure data deposition date) |
![]() | Kovalevsky, A.Y. / Liu, F. / Leshchenko, S. / Ghosh, A.K. / Louis, J.M. / Harrison, R.W. / Weber, I.T. |
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Methods | X-ray diffraction |
Resolution | 0.84 - 1.22 Å |
Structure data | ![]() PDB-2hs1: ![]() PDB-2hs2: |
Chemicals | ![]() ChemComp-CL: ![]() ChemComp-017: ![]() ChemComp-DMS: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / ultra-high resolution active site surface binding site / aspartic protease active site surface binding site |