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TitleAcidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 28951-28957, Year 2006
Publish dateJun 18, 2006 (structure data deposition date)
AuthorsGraeff, R. / Liu, Q. / Kriksunov, I.A. / Hao, Q. / Lee, H.C.
External linksJ. Biol. Chem. / PubMed:16861223
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-2hct:
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-NMN:
BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / BETA SHEETS / ALPHA BUNDLE

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