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TitleIdentification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 4834-4838, Year 2006
Publish dateJun 12, 2006 (structure data deposition date)
AuthorsLi, H. / Tatlock, J. / Linton, A. / Gonzalez, J. / Borchardt, A. / Dragovich, P. / Jewell, T. / Prins, T. / Zhou, R. / Blazel, J. ...Li, H. / Tatlock, J. / Linton, A. / Gonzalez, J. / Borchardt, A. / Dragovich, P. / Jewell, T. / Prins, T. / Zhou, R. / Blazel, J. / Parge, H. / Love, R. / Hickey, M. / Doan, C. / Shi, S. / Duggal, R. / Lewis, C. / Fuhrman, S.
External linksBioorg. Med. Chem. Lett. / PubMed:16824756
MethodsX-ray diffraction
Resolution1.58 Å
Structure data

PDB-2hai:
Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

ChemComp-PFI:
(6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsTRANSFERASE / HCV RNA Polymerase

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