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Structure paper

TitleStructural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 4953-4960, Year 2006
Publish dateFeb 3, 2006 (structure data deposition date)
AuthorsImmormino, R.M. / Kang, Y. / Chiosis, G. / Gewirth, D.T.
External linksJ. Med. Chem. / PubMed:16884307
MethodsX-ray diffraction
Resolution2 - 2.1 Å
Structure data

PDB-2fwy:
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2fwz:
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2h55:
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-H64:
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE

ChemComp-HOH:
WATER

ChemComp-H71:
8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE

ChemComp-DZ8:
2-FLUORO-8-[(6-IODO-1,3-BENZODIOXOL-5-YL)METHYL]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE

Source
  • homo sapiens (human)
KeywordsCHAPERONE / HSP90 / GRP94 / purine / PU3 / H64 / H71 / DZ8

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