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Structure paper

TitleCrystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
Journal, issue, pagesBiochem. J., Vol. 401, Page 39-47, Year 2007
Publish dateMay 14, 2006 (structure data deposition date)
AuthorsLi, S. / Lu, Y. / Peng, B. / Ding, J.
External linksBiochem. J. / PubMed:16939420
MethodsX-ray diffraction
Resolution2.2 - 2.5 Å
Structure data

PDB-2h06:
Crystal structure of human phosphoribosyl pyrophosphate synthetase 1
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2h07:
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant S132A
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2h08:
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant Y146M
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2hcr:
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with AMP(ATP), cadmium and sulfate ion
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CD:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PRS1 / prpp synthetase 1 / phosphoribosyl pyrophosphate synthetase 1 / mutant / phosphoribosyl pyrophosphate 1

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