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TitlePlatensimycin is a selective FabF inhibitor with potent antibiotic properties.
Journal, issue, pagesNature, Vol. 441, Page 358-361, Year 2006
Publish dateMar 23, 2006 (structure data deposition date)
AuthorsWang, J. / Soisson, S.M. / Young, K. / Shoop, W. / Kodali, S. / Galgoci, A. / Painter, R. / Parthasarathy, G. / Tang, Y.S. / Cummings, R. ...Wang, J. / Soisson, S.M. / Young, K. / Shoop, W. / Kodali, S. / Galgoci, A. / Painter, R. / Parthasarathy, G. / Tang, Y.S. / Cummings, R. / Ha, S. / Dorso, K. / Motyl, M. / Jayasuriya, H. / Ondeyka, J. / Herath, K. / Zhang, C. / Hernandez, L. / Allocco, J. / Basilio, A. / Tormo, J.R. / Genilloud, O. / Vicente, F. / Pelaez, F. / Colwell, L. / Lee, S.H. / Michael, B. / Felcetto, T. / Gill, C. / Silver, L.L. / Hermes, J.D. / Bartizal, K. / Barrett, J. / Schmatz, D. / Becker, J.W. / Cully, D. / Singh, S.B.
External linksNature / PubMed:16710421
MethodsX-ray diffraction
Resolution2.29 - 2.85 Å
Structure data

PDB-2gfv:
Structure of E. coli FabF (KASII) C163Q mutant
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

PDB-2gfw:
Structure of wild type E. coli FabF (KASII)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2gfx:
Structure of E. coli FabF(C163Q) in complex with Platensimycin
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-2gfy:
Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PMN:
PLATENSIMYCIN / antibiotic*YM

ChemComp-DAO:
LAURIC ACID

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / FabF; KASII; acyl-enzyme intermediate / FabF; KASII; ketoacyl synthase / FabF; KASII; ketoacyl synthase; platensimycin

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