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TitleCavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.
Journal, issue, pagesBiochemistry, Vol. 45, Page 11703-11711, Year 2006
Publish dateMar 15, 2006 (structure data deposition date)
AuthorsIancu, C.V. / Zhou, Y. / Borza, T. / Fromm, H.J. / Honzatko, R.B.
External linksBiochemistry / PubMed:16981730
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-2dgn:
Mouse Muscle Adenylosuccinate Synthetase partially ligated complex with GTP, 2'-deoxy-IMP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2gcq:
Fully ligated E.Coli Adenylosuccinate Synthetase with GTP, 2'-deoxy-IMP and Hadacidin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-DOI:
9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-6-(PHOSPHONOOXY)-9H-PURINE

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-HDA:
HADACIDIN / anticancer, medication*YM

Source
  • mus musculus (house mouse)
  • escherichia coli (E. coli)
KeywordsLIGASE / Adenylosuccinate synthetase / GTP / ADSS1 / 2'-deoxy-IMP / Adenylosuccinate synthetase; ADSS; GTP; Hadacidin; 2'-deoxy-IMP

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