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TitleHydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
Journal, issue, pagesChem. Biol., Vol. 11, Page 1719-1728, Year 2004
Publish dateFeb 23, 2006 (structure data deposition date)
AuthorsPurkey, H.E. / Palaninathan, S.K. / Kent, K.C. / Smith, C. / Safe, S.H. / Sacchettini, J.C. / Kelly, J.W.
External linksChem. Biol. / PubMed:15610856
MethodsX-ray diffraction
Resolution1.8 - 1.85 Å
Structure data

PDB-2g5u:
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2g9k:
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2gab:
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-PCQ:
3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL

ChemComp-HOH:
WATER

ChemComp-NE1:
2',3,3',4',5-PENTACHLOROBIPHENYL-4-OL

ChemComp-NE2:
3,3',4',5-TETRACHLOROBIPHENYL-4-OL

Source
  • homo sapiens (human)
KeywordsHORMONE/GROWTH FACTOR / TTR / AMYLOID / TRANSTHYRETIN / HORMONE-GROWTH FACTOR COMPLEX

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