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TitleA novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Journal, issue, pagesMol. Endocrinol., Vol. 20, Page 809-830, Year 2006
Publish dateJan 31, 2006 (structure data deposition date)
AuthorsBurgermeister, E. / Schnoebelen, A. / Flament, A. / Benz, J. / Stihle, M. / Gsell, B. / Rufer, A. / Ruf, A. / Kuhn, B. / Maerki, H.P. ...Burgermeister, E. / Schnoebelen, A. / Flament, A. / Benz, J. / Stihle, M. / Gsell, B. / Rufer, A. / Ruf, A. / Kuhn, B. / Maerki, H.P. / Mizrahi, J. / Sebokova, E. / Niesor, E. / Meyer, M.
External linksMol. Endocrinol. / PubMed:16373399
MethodsX-ray diffraction
Resolution1.99 Å
Structure data

PDB-2fvj:
A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-RO0:
1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Nuclear Receptor LBD / Alpha Helical Sandwich

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