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TitleMutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 8205-8215, Year 2006
Publish dateJan 6, 2006 (structure data deposition date)
AuthorsYi, M. / Tong, X. / Skelton, A. / Chase, R. / Chen, T. / Prongay, A. / Bogen, S.L. / Saksena, A.K. / Njoroge, F.G. / Veselenak, R.L. ...Yi, M. / Tong, X. / Skelton, A. / Chase, R. / Chen, T. / Prongay, A. / Bogen, S.L. / Saksena, A.K. / Njoroge, F.G. / Veselenak, R.L. / Pyles, R.B. / Bourne, N. / Malcolm, B.A. / Lemon, S.M.
External linksJ. Biol. Chem. / PubMed:16352601
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-2fm2:
HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-3BC:
TERT-BUTYL

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsHYDROLASE / Hepatitis C Virus / HCV / NS3/4A protease / ketoamide inhibitor

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