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Title(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 3614-3627, Year 2006
Publish dateJan 3, 2006 (structure data deposition date)
AuthorsEdmondson, S.D. / Mastracchio, A. / Mathvink, R.J. / He, J. / Harper, B. / Park, Y.J. / Beconi, M. / Di Salvo, J. / Eiermann, G.J. / He, H. ...Edmondson, S.D. / Mastracchio, A. / Mathvink, R.J. / He, J. / Harper, B. / Park, Y.J. / Beconi, M. / Di Salvo, J. / Eiermann, G.J. / He, H. / Leiting, B. / Leone, J.F. / Levorse, D.A. / Lyons, K. / Patel, R.A. / Patel, S.B. / Petrov, A. / Scapin, G. / Shang, J. / Roy, R.S. / Smith, A. / Wu, J.K. / Xu, S. / Zhu, B. / Thornberry, N.A. / Weber, A.E.
External linksJ. Med. Chem. / PubMed:16759103
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-2fjp:
Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-S14:
6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ALPHA/BETA / BETA-PROPELLER / DIMER

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