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TitleStructure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Journal, issue, pagesMol. Microbiol., Vol. 59, Page 1417-1428, Year 2006
Publish dateDec 23, 2005 (structure data deposition date)
AuthorsHu, G. / Lin, G. / Wang, M. / Dick, L. / Xu, R.M. / Nathan, C. / Li, H.
External linksMol. Microbiol. / PubMed:16468986
MethodsX-ray diffraction
Resolution2.99 - 3.23 Å
Structure data

PDB-2fhg:
Crystal Structure of Mycobacterial Tuberculosis Proteasome
Method: X-RAY DIFFRACTION / Resolution: 3.23 Å

PDB-2fhh:
Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-M1N:
(1R)-3-METHYL-1-{[N-(MORPHOLIN-4-YLCARBONYL)-3-(1-NAPHTHYL)-D-ALANYL]AMINO}BUTYLBORONIC ACID

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsHYDROLASE / multi-protein / multi-subunit complex / protease / proteasome / multi-subunit protein assembly / inhibitor-complex

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