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TitleCrystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
Journal, issue, pagesEMBO J., Vol. 17, Page 5896-5904, Year 1998
Publish dateSep 15, 1998 (structure data deposition date)
AuthorsMohammadi, M. / Froum, S. / Hamby, J.M. / Schroeder, M.C. / Panek, R.L. / Lu, G.H. / Eliseenkova, A.V. / Green, D. / Schlessinger, J. / Hubbard, S.R.
External linksEMBO J. / PubMed:9774334
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-2fgi:
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PD1:
1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / TYROSINE-PROTEIN KINASE / ATP-BINDING / PHOSPHORYLATION / INHIBITOR

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