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Structure paper

TitleSynthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 125, Page 13404-13414, Year 2003
Publish dateDec 9, 2005 (structure data deposition date)
AuthorsGreen, N.S. / Palaninathan, S.K. / Sacchettini, J.C. / Kelly, J.W.
External linksJ. Am. Chem. Soc. / PubMed:14583036
MethodsX-ray diffraction
Resolution1.46 - 1.65 Å
Structure data

PDB-2fbr:
Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (4 carbon linker)
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-2flm:
Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-44C:
4'-(4-{4-[(2-CARBOXYPHENYL)AMINO]PHENOXY}BUTOXY)-1,1'-BIPHENYL-4-CARBOXYLIC ACID

ChemComp-HOH:
WATER

ChemComp-6CA:
4'-{6-[4-(2-CARBOXYPHENYLAMINO)-PHENOXY]-HEXYLOXY}-BIPHENYL-4-CARBOXYLIC ACID

Source
  • homo sapiens (human)
KeywordsHORMONE/GROWTH FACTOR / TTR / AMYLOID / TRANSTHYRETIN / HORMONE-GROWTH FACTOR COMPLEX

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