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TitleCrystal structure of human BACE2 in complex with a hydroxyethylamine transition state inhibitor
Journal, issue, pagesJ. Mol. Biol., Vol. 355, Page 249-261, Year 2006
Publish dateNov 7, 2005 (structure data deposition date)
AuthorsOstermann, N. / Eder, J. / Eidhoff, U. / Zink, F. / Hassiepen, U. / Worpenberg, S. / Maibaum, J. / Simic, O. / Hommel, U. / Gerhartz, B.
External linksJ. Mol. Biol. / PubMed:16305800
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-2ewy:
Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-DBO:
N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / BACE2 / aspartic protease

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