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-Structure paper
Title | Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 2817-2822, Year 2007 |
Publish date | Jan 30, 2007 (structure data deposition date) |
![]() | Wang, G.T. / Mantei, R.A. / Kawai, M. / Tedrow, J.S. / Barnes, D.M. / Wang, J. / Zhang, Q. / Lou, P. / Garcia, L.A. / Bouska, J. ...Wang, G.T. / Mantei, R.A. / Kawai, M. / Tedrow, J.S. / Barnes, D.M. / Wang, J. / Zhang, Q. / Lou, P. / Garcia, L.A. / Bouska, J. / Yates, M. / Park, C. / Judge, R.A. / Lesniewski, R. / Sheppard, G.S. / Bell, R.L. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.35 - 2.5 Å |
Structure data | ![]() PDB-2ea2: ![]() PDB-2ea4: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-F77: ![]() ChemComp-HOH: ![]() ChemComp-F79: |
Source |
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![]() | HYDROLASE / Protein-ligand complex |