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Structure paper

TitleSordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 657-666, Year 2007
Publish dateOct 27, 2006 (structure data deposition date)
AuthorsSoe, R. / Mosley, R.T. / Justice, M. / Nielsen-Kahn, J. / Shastry, M. / Merrill, A.R. / Andersen, G.R.
External linksJ. Biol. Chem. / PubMed:17082187
MethodsX-ray diffraction
Resolution2.9 - 3.15 Å
Structure data

PDB-2e1r:
Structure of eEF2 in complex with a sordarin derivative
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-2npf:
Structure of eEF2 in complex with moriniafungin
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-SOD:
(1S,4S,5S,6R,9S,11S)-6-CHLORO-9-FORMYL-13-ISOPROPYL-5-METHYL-2-({[(3AR,5R,7R ,7AS)-7-METHYL-3-METHYLENEHEXAHYDRO-2H-FURO[2,3-C]PYRAN-5-YL]OXY}METHYL)TETR ACYCLO[7.4.0.02,11.04,8]TRIDEC-12-ENE-1-CARBOXYLIC ACI

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MOU:
(1S,4R,5R,9S,11S)-2-({[(2S,5R,6R,7R,9S,10R)-2-(7-CARBOXYHEPTYL)-6-HYDROXY-10-METHOXY-9-METHYL-3-OXO-1,4,8-TRIOXASPIRO[4

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSLATION / protein-ligand complex / G-protein / protein-inhibitor complex

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