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TitleCrystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 7526-7532, Year 2006
Publish dateJun 17, 2005 (structure data deposition date)
AuthorsFu, Z. / Runquist, J.A. / Forouhar, F. / Hussain, M. / Hunt, J.F. / Miziorko, H.M. / Kim, J.-J.P.
External linksJ. Biol. Chem. / PubMed:16330550
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-2cw6:
Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-3HG:
3-HYDROXYPENTANEDIOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / HMG-CoA Lyase / Ketogenic Enzyme

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