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Structure paper

TitleTrans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Journal, issue, pagesEmbo J., Vol. 25, Page 3179-, Year 2006
Publish dateMay 18, 2006 (structure data deposition date)
AuthorsOliver, A.W. / Paul, A. / Boxall, K.J. / Barrie, S.E. / Aherne, G.W. / Garrett, M.D. / Mittnacht, S. / Pearl, L.H.
External linksEmbo J. / PubMed:16794575
MethodsX-ray diffraction
Resolution2.25 - 2.7 Å
Structure data

PDB-2cn5:
Crystal structure of human Chk2 in complex with ADP
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2cn8:
Crystal structure of human Chk2 in complex with debromohymenialdisine
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-NO3:
NITRATE ION

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-DBQ:
DEBROMOHYMENIALDISINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / KINASE DOMAIN / CHECKPOINT / CANCER / TUMOUR SUPPRESSOR / CHEK2 / CHK2 / CDS1 / RAD53 / PHOSPHORYLATION / ACTIVATION SEGMENT / LI-FRAUMENI SYNDROME / ATP-BINDING / CELL CYCLE / DISEASE MUTATION / MAGNESIUM / METAL-BINDING / NUCLEAR PROTEIN / NUCLEOTIDE-BINDING / PROTO-ONCOGENE / SERINE/THREONINE-PROTEIN KINASE / HYPOTHETICAL PROTEIN

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