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Structure paper

TitleStructural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 3293-3301, Year 2007
Publish dateMar 9, 2006 (structure data deposition date)
AuthorsHewitson, K. / Lienard, B. / McDonough, M.A. / Clifton, I.J. / Butler, D. / Soares, A.S. / Oldham, N.J. / McNeill, L.A. / Schofield, C.J.
External linksJ. Biol. Chem. / PubMed:17135241
MethodsX-ray diffraction
Resolution2.3 - 2.4 Å
Structure data

PDB-2cgn:
FACTOR INHIBITING HIF-1 ALPHA with succinate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2cgo:
FACTOR INHIBITING HIF-1 ALPHA with fumarate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-SIN:
SUCCINIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-FUM:
FUMARIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 2-OXOGLUTARATE / ACETYLATION / ACTIVATOR / ALTERNATIVE SPLICING / ASPARAGINYL HYDROXYLASE / DNA-BINDING / DSBH / FI / HIF / HYDROXYLATION / HYPOXIA / NUCLEAR PROTEIN / OXYGENASE / PHOSPHORYLATION / POLYMORPHISM / S-NITROSYLATION / TRANSCRIPTION / TRANSCRIPTION ACTIVATOR/INHIBITOR / TRANSCRIPTION REGULATION / DIOXYGENASE / IRON / METAL-BINDING

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