EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 16, Page 1353-, Year 2006
掲載日	2005年11月8日 (構造データの登録日)
著者	Richardson, C.M. / Williamson, D.S. / Parratt, M.J. / Borgognoni, J. / Cansfield, A.D. / Dokurno, P. / Francis, G.L. / Howes, R. / Moore, J.D. / Murray, J.B. ...Richardson, C.M. / Williamson, D.S. / Parratt, M.J. / Borgognoni, J. / Cansfield, A.D. / Dokurno, P. / Francis, G.L. / Howes, R. / Moore, J.D. / Murray, J.B. / Robertson, A. / Surgenor, A.E. / Torrance, C.J.
リンク	Bioorg. Med. Chem. Lett. / PubMed:16325401
手法	X線回折
解像度	1.8 - 2.61 Å
構造データ	PDB-2c68: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-2c69: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2c6i: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2c6k: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2c6l: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2c6m: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2c6o: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2c6t: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å
化合物	ChemComp-CT6: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE ChemComp-HOH: WATER ChemComp-CT8: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE ChemComp-DT1: 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE ChemComp-DT2: 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE ChemComp-DT4: 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE ChemComp-DT5: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE ChemComp-4SP: O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE / NU-6102
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / SERINE/THREONINE PROTEIN KINASE / CDK2 / ATP-BINDING / CELL CYCLE / MITOSIS / PHOSPHORYLATION / TRIAZOLOPYRIMIDINE INHIBITOR / CELL DIVISION / KINASE / POLYMORPHISM / NUCLEOTIDE-BINDING / COMPLEX (TRANSFERASE-CYCLIN2)