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Structure paper

TitleStructure-Based Discovery of a New Class of Hsp90 Inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 5187-, Year 2005
Publish dateAug 11, 2005 (structure data deposition date)
AuthorsBarril, X. / Brough, P. / Drysdale, M. / Hubbard, R.E. / Massey, A. / Surgenor, A. / Wright, L.
External linksBioorg. Med. Chem. Lett. / PubMed:16202589
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2bz5:
Structure-based Discovery of a New Class of Hsp90 Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-AB4:
2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCHAPERONE / ATP-BINDING / HEAT SHOCK / NUCLEOTIDE-BINDING / PHOSPHORYLATION

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