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TitleA Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 31754-, Year 2005
Publish dateJul 12, 2005 (structure data deposition date)
AuthorsSteegborn, C. / Litvin, T.N. / Hess, K.C. / Capper, A.B. / Taussig, R. / Buck, J. / Levin, L.R. / Wu, H.
External linksJ. Biol. Chem. / PubMed:16002394
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2bw7:
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-APC:
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER / AMP-CPP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-ECS:
2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE

ChemComp-HOH:
WATER

Source
  • spirulina platensis (bacteria)
KeywordsLYASE / ADENYLYL CYCLASE / CAMP SIGNALING / CATECHOL ESTROGEN / INHIBITOR COMPLEX / OXIDOREDUCTASE

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