Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Journal, issue, pages	J. Med. Chem., Vol. 48, Page 4212-4215, Year 2005
Publish date	May 23, 2005 (structure data deposition date)
Authors	Dymock, B.W. / Barril, X. / Brough, P.A. / Cansfield, J.E. / Massey, A. / McDonald, E. / Hubbard, R.E. / Surgenor, A. / Roughley, S.D. / Webb, P. ...Dymock, B.W. / Barril, X. / Brough, P.A. / Cansfield, J.E. / Massey, A. / McDonald, E. / Hubbard, R.E. / Surgenor, A. / Roughley, S.D. / Webb, P. / Workman, P. / Wright, L. / Drysdale, M.J.
External links	J. Med. Chem. / PubMed:15974572
Methods	X-ray diffraction
Resolution	1.9 - 2.05 Å
Structure data	PDB-2bsm: Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design Method: X-RAY DIFFRACTION / Resolution: 2.05 Å PDB-2bt0: Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design Method: X-RAY DIFFRACTION / Resolution: 1.9 Å
Chemicals	ChemComp-BSM: 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE ChemComp-HOH: WATER ChemComp-CT5: 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
Source	homo sapiens (human)
Keywords	CHAPERONE / HSP90 / ATPASE / PU3 / ATP-BINDING / HEAT SHOCK / PHOSPHORYLATION