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Title | Structural Requirements for Factor Xa Inhibition by 3-Oxybenzamides with Neutral P1 Substituents: Combining X-Ray Crystallography, 3D-Qsar and Tailored Scoring Functions |
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Journal, issue, pages | J. Med. Chem., Vol. 48, Page 3290-, Year 2005 |
Publish date | Mar 14, 2005 (structure data deposition date) |
Authors | Matter, H. / Will, D.W. / Nazare, M. / Schreuder, H. / Laux, V. / Wehner, V. / Liesum, A. |
External links | J. Med. Chem. / PubMed:15857135 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-2bmg: |
Chemicals | ChemComp-CA: ChemComp-I1H: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / THROMBOSIS / PROTEIN INHIBITOR COMPLEX / BLOOD COAGULATION FACTOR / SERINE PROTEINASE / DRUG DESIGN |