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| Title | Structure Based Design of 4-(3-Aminomethylphenyl) Piperidinyl-1-Amides: Novel, Potent, Selective, and Orally Bioavailable Inhibitors of Bii Tryptase |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem., Vol. 13, Page 2859-, Year 2005 |
| Publish date | Mar 9, 2005 (structure data deposition date) |
Authors | Levell, J. / Astles, P. / Eastwood, P. / Cairns, J. / Houille, O. / Aldous, S. / Merriman, G. / Whitley, B. / Pribish, J. / Czekaj, M. ...Levell, J. / Astles, P. / Eastwood, P. / Cairns, J. / Houille, O. / Aldous, S. / Merriman, G. / Whitley, B. / Pribish, J. / Czekaj, M. / Liang, G. / Maignan, S. / Guilloteau, J.-P. / Dupuy, A. / Davidson, J. / Harrison, T. / Morley, A. / Watson, S. / Fenton, G. / Mccarthy, C. / Romano, J. / Mathew, R. / Engers, D. / Gardyan, M. / Sides, K. / Kwong, J. / Tsay, J. / Rebello, S. / Shen, L. / Wang, J. / Luo, Y. / Giardino, O. / Lim, H.-K. / Smith, K. / Pauls, H. |
External links | Bioorg. Med. Chem. / PubMed:15781396 |
| Methods | X-ray diffraction |
| Resolution | 2.2 Å |
| Structure data | ![]() PDB-2bm2: |
| Chemicals | ![]() ChemComp-PM2: ![]() ChemComp-HOH: |
| Source |
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Keywords | HYDROLASE / SERINE PROTEASE INHIBITOR / GLYCOPROTEIN / POLYMORPHISM / PROTEASE / SERINE PROTEASE |
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homo sapiens (human)
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