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TitleCrystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 102, Page 13046-, Year 2005
Publish dateMar 2, 2005 (structure data deposition date)
AuthorsKongsaeree, P. / Khongsuk, P. / Leartsakulpanich, U. / Chitnumsub, P. / Tarnchompoo, B. / Walkinshaw, M.D. / Yuthavong, Y.
External linksProc. Natl. Acad. Sci. USA / PubMed:16135570
MethodsX-ray diffraction
Resolution1.9 - 3 Å
Structure data

PDB-2bl9:
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2bla:
SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2blb:
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2blc:
SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-CP6:
5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE / medication, antiparasitic*YM

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CP7:
6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE

Source
  • plasmodium vivax (malaria parasite P. vivax)
KeywordsOXIDOREDUCTASE / DIHYDROFOLATE REDUCTASE / PLAMODIUM VIVAX / PYRIMETHAMINE / MALARIA / DRUG RESISTANCE / PLASMODIUM VIVAX / THYMIDYLATE SYNTHASE / DOUBLE MUTANT

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