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Structure paper

TitleMechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Journal, issue, pagesMol. Cell, Vol. 18, Page 379-, Year 2005
Publish dateDec 15, 2004 (structure data deposition date)
AuthorsSessa, F. / Mapelli, M. / Ciferri, C. / Tarricone, C. / Areces, L.B. / Schneider, T.R. / Stukenberg, P.T. / Musacchio, A.
External linksMol. Cell / PubMed:15866179
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2bfx:
Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2bfy:
Complex of Aurora-B with INCENP and Hesperadin.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-H1N:
N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE / inhibitor*YM

Source
  • xenopus laevis (African clawed frog)
KeywordsTRANSFERASE / KINASE / MITOSIS / INHIBITION / TRANSFERASE COMPLEX

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