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TitleThe High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture
Journal, issue, pagesTo be Published
Publish dateNov 25, 2004 (structure data deposition date)
AuthorsWu, X. / Kavanagh, K. / Svensson, S. / Elleby, B. / Hult, M. / von Delft, F. / Marsden, B. / Jornvall, H. / Abrahmsen, L. / Oppermann, U.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-2bel:
Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-CBO:
CARBENOXOLONE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / GLUCOCORTICOID ACTIVATION / DRUG TARGET / INHIBITOR / SHORT-CHAIN DEHYDROGENASE/REDUCTASE / HORMONE METABOLISM / MICROSOME / NADP / STEROID METABOLISM

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