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Structure paper

TitleNovel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 1735-1739, Year 2006
Publish dateOct 20, 2005 (structure data deposition date)
AuthorsBarrett, D.G. / Catalano, J.G. / Deaton, D.N. / Hassell, A.M. / Long, S.T. / Miller, A.B. / Miller, L.R. / Ray, J.A. / Samano, V. / Shewchuk, L.M. ...Barrett, D.G. / Catalano, J.G. / Deaton, D.N. / Hassell, A.M. / Long, S.T. / Miller, A.B. / Miller, L.R. / Ray, J.A. / Samano, V. / Shewchuk, L.M. / Wells-Knecht, K.J. / Willard Jr., D.H. / Wright, L.L.
External linksBioorg. Med. Chem. Lett. / PubMed:16376075
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2bdl:
Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-4PR:
(3S)-1-{[(3,5-DIMETHYLISOXAZOL-4-YL)AMINO]CARBONYL}-4,4-DIMETHYLPYRROLIDIN-3-YL{(1S)-1-[1-HYDROXY-2-OXO-2-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL]PENTYL}CARBAMATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / cathepsin / cysteine protease / catK / catO

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