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Structure paper

TitleDiflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Journal, issue, pagesJ. Med. Chem., Vol. 47, Page 355-374, Year 2004
Publish dateOct 3, 2005 (structure data deposition date)
AuthorsAdamski-Werner, S.L. / Palaninathan, S.K. / Sacchettini, J.C. / Kelly, J.W.
External linksJ. Med. Chem. / PubMed:14711308
MethodsX-ray diffraction
Resolution1.54 - 1.85 Å
Structure data

PDB-2b77:
Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2b9a:
Human transthyretin (TTR) complexed with diflunisal analogues- TTR.3',5'-difluorobiphenyl-4-carboxylic acid
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-2f7i:
Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-3d2t:
Human transthyretin (ttr) complexed with diflunisal
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-3CA:
2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID

ChemComp-HOH:
WATER

ChemComp-FBC:
3',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID

ChemComp-26C:
2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID

ChemComp-1FL:
5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID / antiinflammatory*YM

Source
  • homo sapiens (human)
KeywordsHORMONE/GROWTH FACTOR / TTR / Amyloid / Transthyretin / HORMONE-GROWTH FACTOR COMPLEX / HORMONE / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Polyneuropathy / Retinol-binding / Secreted / Thyroid hormone / Transport / Vitamin A

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