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TitleA selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 6772-6775, Year 2005
Publish dateSep 7, 2005 (structure data deposition date)
AuthorsHummel, C.W. / Geiser, A.G. / Bryant, H.U. / Cohen, I.R. / Dally, R.D. / Fong, K.C. / Frank, S.A. / Hinklin, R. / Jones, S.A. / Lewis, G. ...Hummel, C.W. / Geiser, A.G. / Bryant, H.U. / Cohen, I.R. / Dally, R.D. / Fong, K.C. / Frank, S.A. / Hinklin, R. / Jones, S.A. / Lewis, G. / McCann, D.J. / Rudman, D.G. / Shepherd, T.A. / Tian, H. / Wallace, O.B. / Wang, Y. / Dodge, J.A.
External linksJ. Med. Chem. / PubMed:16250633
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2ayr:
A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-L4G:
6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / receptor / transcription regulation / ligand-binding / SERM

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