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TitleAcyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 6178-6193, Year 2005
Publish dateAug 25, 2005 (structure data deposition date)
AuthorsKlabunde, T. / Wendt, K.U. / Kadereit, D. / Brachvogel, V. / Burger, H.J. / Herling, A.W. / Oikonomakos, N.G. / Kosmopoulou, M.N. / Schmoll, D. / Sarubbi, E. ...Klabunde, T. / Wendt, K.U. / Kadereit, D. / Brachvogel, V. / Burger, H.J. / Herling, A.W. / Oikonomakos, N.G. / Kosmopoulou, M.N. / Schmoll, D. / Sarubbi, E. / von Roedern, E. / Defossa, E.
External linksJ. Med. Chem. / PubMed:16190745
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2ati:
Glycogen Phosphorylase Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-IHU:
N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Glycogen Phosphorylase

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