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Structure paper

TitleMechanism of positive allosteric modulators acting on AMPA receptors.
Journal, issue, pagesJ. Neurosci., Vol. 25, Page 9027-9036, Year 2005
Publish dateAug 4, 2005 (structure data deposition date)
AuthorsJin, R. / Clark, S. / Weeks, A.M. / Dudman, J.T. / Gouaux, E. / Partin, K.M.
External linksJ. Neurosci. / PubMed:16192394
MethodsX-ray diffraction
Resolution1.65 - 1.7 Å
Structure data

PDB-2al4:
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2al5:
Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-QUS:
(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID / agonist*YM

ChemComp-CX6:
2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE

ChemComp-HOH:
WATER

ChemComp-FWD:
2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID

ChemComp-4MP:
1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE / medication*YM

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / IONOTROPIC GLUTAMATE RECEPTOR / GLUR2 / LIGAND BINDING CORE / S1S2 / quisqualate / CX614 / modulator / FLUORO-WILLARDIINE / aniracetam

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