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Structure paper

TitleStructure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution.
Journal, issue, pagesJ. Mol. Biol., Vol. 352, Page 1091-1104, Year 2005
Publish dateJul 25, 2005 (structure data deposition date)
AuthorsSampathkumar, P. / Turley, S. / Ulmer, J.E. / Rhie, H.G. / Sibley, C.H. / Hol, W.G.
External linksJ. Mol. Biol. / PubMed:16139296
MethodsX-ray diffraction
Resolution2.01 Å
Structure data

PDB-2af6:
Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-BRU:
5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsTRANSFERASE / M.tuberculosis / ThyX / FDTS / TSCP / flavin dependent thymidylate synthase

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