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Title4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 5644-5647, Year 2005
Publish dateJul 20, 2005 (structure data deposition date)
AuthorsKallander, L.S. / Lu, Q. / Chen, W. / Tomaszek, T. / Yang, G. / Tew, D. / Meek, T.D. / Hofmann, G.A. / Schulz-Pritchard, C.K. / Smith, W.W. ...Kallander, L.S. / Lu, Q. / Chen, W. / Tomaszek, T. / Yang, G. / Tew, D. / Meek, T.D. / Hofmann, G.A. / Schulz-Pritchard, C.K. / Smith, W.W. / Janson, C.A. / Ryan, M.D. / Zhang, G.F. / Johanson, K.O. / Kirkpatrick, R.B. / Ho, T.F. / Fisher, P.W. / Mattern, M.R. / Johnson, R.K. / Hansbury, M.J. / Winkler, J.D. / Ward, K.W. / Veber, D.F. / Thompson, S.K.
External linksJ. Med. Chem. / PubMed:16134930
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2adu:
Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-R20:
4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / aminopeptidase / metal binding / protease

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